Early stage primary gastric diffuse large B-cell lymphoma in a young HIV-positive patient
| Autor: | Aloísio Felipe-Silva, Guilherme Harada, José Guilherme Nogueira da Silva |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
lcsh:Internal medicine
medicine.medical_specialty Lymphoma Population lcsh:Medicine Malignancy Gastroenterology Pathology and Forensic Medicine Stomach Neoplasms Internal medicine Biopsy Large B-Cell Internal Medicine medicine Stage (cooking) lcsh:RC31-1245 education AIDS-Related Lymphoma AIDS-Related Acquired Immunodeficiency Syndrome education.field_of_study medicine.diagnostic_test business.industry lcsh:R Respiratory infection medicine.disease Diffuse SÍNDROME DE IMUNODEFICIÊNCIA ADQUIRIDA Regimen Relative risk Artigo / Relato de Caso Clínico Lymphoma Large B-Cell Diffuse business Article / Clinical Case Reports |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP Autopsy & Case Reports Autopsy and Case Reports, Vol 4, Iss 2 (2014) |
| ISSN: | 2236-1960 |
| DOI: | 10.4322/acr.2014.014 |
| Popis: | HIV infection is known to be associated with the development of a wide range of neoplasia. About 25 to 40% of HIV-positive patients will present some kind of malignancy in the course of the disease; among them 10% are non-Hodgkin lymphomas (NHL) and 20% of these are represented by the diffuse large B-cell lymphoma. HIV-positive patients have a relative risk of 110 times higher to develop neoplasia, than the non-infected population. The gastrointestinal (GI) tract is the most frequent extranodal site of involvement. However, the primary GI lymphoma is rare. The authors present a case of a 31-year-old male patient with a 16-year history of HIV infection, who deliberately withdrew the Highly Active Antiretroviral Therapy (HAART) regimen and was hospitalized because of a respiratory infection. Because of a long-term complaint of dyspepsia, an upper gastrointestinal endoscopy was performed disclosing a large elevated and ulcerated gastric lesion, which biopsy revealed a diffuse large B-cell lymphoma. Clinical, imaging and laboratory tests showed an early stage diagnosis: Lugano stage I. Although not frequent, the authors alert to considering this neoplasia in all HIV-positive patients with dyspeptic symptoms. |
| Databáze: | OpenAIRE |
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