Donepezil Combined with DL-3-n-Butylphthalide Delays Cognitive Decline in Patients with Mild to Moderate Alzheimer's Disease: A Multicenter, Prospective Cohort Study
| Autor: | Qingyun Quan, Hang Su, Hong Zhang, Xiaojuan Guo, Jin Wang, Wenhui Lu, Li Ma, Fan Gao, Qiumin Qu, Jie Liu |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Disease Neuropsychological Tests Logistic regression Cohort Studies Alzheimer Disease Internal medicine mental disorders Activities of Daily Living Medicine Humans Cognitive Dysfunction Donepezil Prospective Studies Cognitive decline Adverse effect Prospective cohort study Aged Benzofurans Aged 80 and over business.industry General Neuroscience Therapeutic effect General Medicine Middle Aged Clinical trial Psychiatry and Mental health Clinical Psychology Neuroprotective Agents Treatment Outcome Drug Therapy Combination Female Geriatrics and Gerontology business medicine.drug |
| Zdroj: | Journal of Alzheimer's disease : JAD. 80(2) |
| ISSN: | 1875-8908 |
| Popis: | Background: Vascular factors and mitochondria dysfunction contribute to the pathogenesis of Alzheimer’s disease (AD). DL-3-n-butylphthalide (NBP) has an effect in protecting mitochondria and improving microcirculation. Objective: The aim was to investigate the effect of donepezil combined NBP therapy in patients with mild-moderate AD. Methods: It was a prospective cohort study. 92 mild-moderate AD patients were classified into the donepezil alone group (n = 43) or the donepezil combined NBP group (n = 49) for 48 weeks. All patients were evaluated with Alzheimer’s Disease Assessment Scale-Cognitive subscale (ADAS-cog), Clinician’s Interview-Based Impression of Change plus caregiver input (CIBIC-plus), Alzheimer’s Disease Cooperative Study-Activities of Daily Living (ADCS-ADL), and Neuropsychiatric Inventory (NPI) every 12 weeks. All patients were monitored for adverse events (AEs). The efficacy was analyzed using multivariate logistic regression analysis. Results: The multivariate logistic regression analysis showed that the changes of ADAS-cog score (OR = 2.778, 95% CI: [1.087, 7. 100], p = 0.033) and ADCS-ADL score (OR = 2.733, 95% CI: [1.002, 7.459], p = 0.049) had significant difference between donepezil alone group and donepezil combined NBP group, while the changes of NPI (OR = 1.145, 95% CI: [0.463, 2.829], p = 0.769), MMSE (OR = 1.563, 95% CI: [0.615, 3.971], p = 0.348) and CIBIC-plus (OR = 2.593, 95% CI: [0.696, 9.685], p = 0.156) had no significant difference. The occurrence of AEs was similar in the two groups. Conclusion: Over the 48-week treatment period, donepezil combined NBP group had slower cognitive decline and better activities of daily living in patients with mild to moderate AD. These indicated that the multi-target therapeutic effect of NBP may be a new choice for AD treatment. |
| Databáze: | OpenAIRE |
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