Anti-Escherichia coli asparaginase antibody levels determine the activity of second-line treatment with pegylated E coli asparaginase: a retrospective analysis within the ALL-BFM trials
| Autor: | Anja Möricke, Thorsten König, Joachim Gerß, Martin Schrappe, Hans-Jürgen Kühnel, Claudia Lanvers-Kaminsky, Dieter Franke, Arendt von Stackelberg, Günter Henze, Andrea Willer, Joachim Boos |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Asparaginase animal structures Adolescent Immunology Antibody level Antineoplastic Agents Escherichia coli asparaginase Erwinia medicine.disease_cause Biochemistry Antibodies Biomarkers Pharmacological Drug Hypersensitivity chemistry.chemical_compound Young Adult Antineoplastic Combined Chemotherapy Protocols medicine Retrospective analysis Escherichia coli Humans Child Randomized Controlled Trials as Topic Retrospective Studies chemistry.chemical_classification Second line treatment biology Escherichia coli Proteins Daunorubicin Infant Cell Biology Hematology Precursor Cell Lymphoblastic Leukemia-Lymphoma biology.organism_classification Molecular biology Recombinant Proteins Enzyme chemistry Chemotherapy Adjuvant Vincristine Child Preschool Prednisone Drug Monitoring |
| Zdroj: | Blood. 118(22) |
| ISSN: | 1528-0020 |
| Popis: | Hypersensitivity reactions limit the use of the antileukemic enzyme asparaginase (ASE). We evaluated Ab levels against Escherichia coli ASE and ASE activity in 1221 serum samples from 329 patients with acute lymphoblastic leukemia who had received ASE treatment according to the ALL-BFM 2000 or the ALL-REZ BFM 2002 protocol for primary or relapsed disease. ASE activity during first-line treatment with native E coli ASE and second-line treatment with pegylated E coli ASE was inversely related to anti–E coli ASE Ab levels (P < .0001; Spearman rank order correlation). An effect on ASE activity during second-line treatment with pegylated E coli ASE was, however, only observed when anti–E coli ASE Ab levels were high (> 200 AU/mL). In the presence of moderate or intermediate Ab levels (6.25-200 AU/mL) the switch from native to pegylated E coli ASE resulted in a significant increase of ASE activity above the threshold of 100 U/L (P < .05). Erwinia chrysanthemi ASE activity was not correlated with anti–E coli ASE Ab levels. Erwinia ASE was found to be the best ASE alternative if Ab levels against E coli ASE exceed 200 AU/mL. This retrospective analysis is the first to describe the relationship between the level of anti–E coli ASE Abs and serum activity of pegylated E coli ASE used second-line after native E coli ASE. These studies are registered at http://clinicaltrials.org as NTC00430118 and NCT00114348. |
| Databáze: | OpenAIRE |
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