COVID-19 and Acute Neurologic Complications in Children
| Autor: | James W. Antoon, Matt Hall, Leigh M. Howard, Alison Herndon, Katherine L. Freundlich, Carlos G. Grijalva, Derek J. Williams |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Pediatrics. 150 |
| ISSN: | 1098-4275 0031-4005 |
| DOI: | 10.1542/peds.2022-058167 |
| Popis: | BACKGROUND Little is known about the epidemiology and outcomes of neurologic complications associated with coronavirus disease 2019 (COVID-19) in children. METHODS We performed a cross-sectional study of children 2 months to RESULTS Of 15 137 children hospitalized with COVID-19, 1060 (7.0%) had a concurrent diagnosis of a neurologic complication. The most frequent neurologic complications were febrile seizures (3.9%), nonfebrile seizures (2.3%), and encephalopathy (2.2%). Hospital LOS, ICU admission, ICU LOS, 30 day readmissions, deaths, and hospital costs were higher in children with neurologic complications compared with those without complications. Factors associated with lower odds of neurologic complications included: younger age (adjusted odds ratio [aOR]: 0.97; 95% confidence interval [CI]: 0.96–0.98), occurrence during delta variant predominant time period (aOR: 0.71; 95% CI: 0.57–0.87), presence of a nonneurologic complex chronic condition (aOR: 0.80; 95% CI: 0.69–0.94). The presence of a neurologic complex chronic condition was associated with higher odds of neurologic complication (aOR 4.14, 95% CI 3.48–4.92). CONCLUSIONS Neurologic complications are common in children hospitalized with COVID-19 and are associated with worse hospital outcomes. Our findings emphasize the importance of COVID-19 immunization in children, especially in high-risk populations, such as those with neurologic comorbidity. |
| Databáze: | OpenAIRE |
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