Clinical performance and biocompatibility of hyaluronan-based heparin-bonded extracorporeal circuits in different risk cohorts☆

Autor: Serdar Gunaydin, Yaman Zorlutuna, Tamer Sari, Kevin McCusker, Mehmet Ali Onur
Přispěvatelé: Kalp ve Damar Cerrahisi, Kırıkkale Üniversitesi
Rok vydání: 2010
Předmět:
Pulmonary and Respiratory Medicine
medicine.medical_specialty
Time Factors
Respiratory System
Urology
Coronary artery bypass grafting
Risk Assessment
Biomaterial evaluation
law.invention
chemistry.chemical_compound
Coronary artery bypass surgery
Platelet Adhesiveness
Coated Materials
Biocompatible
Risk Factors
law
Internal medicine
Hyaluronic acid
medicine
Cardiopulmonary bypass
Humans
Platelet
Prospective Studies
Coronary Artery Bypass
Hyaluronic Acid
Inflammation
CD11b Antigen
Cardiopulmonary Bypass
Heparin
Interleukin-6
Platelet Count
business.industry
Anticoagulants
EuroSCORE
Complement C3
Treatment Outcome
chemistry
CD18 Antigens
Cardiovascular System & Cardiology
Cardiology
Surgery
Inflammation Mediators
Cardiology and Cardiovascular Medicine
business
Perfusion
Biomarkers
medicine.drug
Zdroj: Interactive CardioVascular and Thoracic Surgery. 10:371-376
ISSN: 1569-9285
1569-9293
DOI: 10.1510/icvts.2009.220756
Popis: ONUR, MEHMET/0000-0002-3630-7982 WOS: 000208480700007 PubMed: 20026488 This prospective randomized study compares novel hyaluronan-based heparin-bonded circuits vs. uncoated controls across EuroSCORE patient risk strata including biomaterial evaluation. Over a two-year period, 90 patients undergoing coronary artery bypass grafting were prospectively randomized to one of the two perfusion protocols: Group 1 was treated with hyaluronan-based heparin-bonded preconnected circuits (Vision HFO-GBS (TM), Gish, CA, USA) and Group 2 with identical uncoated controls. Each group was composed of three subgroups (n = 15) with respect to preoperative evaluation of low (EuroSCORE 0-2), medium (3-5) and high (6+) risk patients. Blood samples were collected after induction (T1) and heparinization (T2), 15 min after cardiopulmonary bypass start (T3), before cessation of CPB (T4), 15 min after reversal (T5), and the first postoperative day (T6). In high-risk patients, platelet counts demonstrated significant preservation at T4, T5 and leukocyte counts were lower at T5 in hyaluronan group (P
Databáze: OpenAIRE
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