Neutrophils in COVID-19
| Autor: | Nico Reusch, Elena De Domenico, Lorenzo Bonaguro, Jonas Schulte-Schrepping, Kevin Baßler, Joachim L. Schultze, Anna C. Aschenbrenner |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
0301 basic medicine 2019-20 coronavirus outbreak Cell type Coronavirus disease 2019 (COVID-19) Mini Review Immunology Severe disease 03 medical and health sciences Functional diversity 0302 clinical medicine Immune deviation neutrophils scRNA-seq immunology [SARS-CoV-2] Immunology and Allergy Medicine Humans immunology [COVID-19] In patient ddc:610 Pandemics immunology [Neutrophils] clinical trials business.industry SARS-CoV-2 COVID-19 granulocytes epidemiology [COVID-19] 3. Good health 030104 developmental biology Homogeneous 030220 oncology & carcinogenesis viral infection lcsh:RC581-607 business |
| Zdroj: | Frontiers in Immunology Frontiers in immunology 12, 652470 (2021). doi:10.3389/fimmu.2021.652470 Frontiers in Immunology, Vol 12 (2021) |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2021.652470 |
| Popis: | Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that neutrophils play an important role in the pathophysiology, particularly in those with severe disease courses. While originally considered to be a rather homogeneous cell type, recent attention to neutrophils has uncovered their fascinating transcriptional and functional diversity as well as their developmental trajectories. These new findings are important to better understand the many facets of neutrophil involvement not only in COVID-19 but also many other acute or chronic inflammatory diseases, both communicable and non-communicable. Here, we highlight the observed immune deviation of neutrophils in COVID-19 and summarize several promising therapeutic attempts to precisely target neutrophils and their reactivity in patients with COVID-19. |
| Databáze: | OpenAIRE |
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