Increased in vitro activity of ceftriaxone by addition of tazobactam against clinical isolates of anaerobes
| Autor: | Kenneth E. Aldridge, Denise D. Schiro, Natchez Morice |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Microbiology (medical)
Tazobactam Penicillanic Acid Microbial Sensitivity Tests Biology Microbiology Bacteria Anaerobic Ampicillin polycyclic compounds medicine organic chemicals Ceftriaxone Broth microdilution General Medicine Sulbactam biochemical phenomena metabolism and nutrition bacterial infections and mycoses biology.organism_classification Anti-Bacterial Agents Infectious Diseases Ticarcillin bacteria Drug Therapy Combination Bacteroides fragilis beta-Lactamase Inhibitors medicine.drug Piperacillin |
| Zdroj: | Diagnostic Microbiology and Infectious Disease. 19:227-234 |
| ISSN: | 0732-8893 |
| DOI: | 10.1016/0732-8893(94)90036-1 |
| Popis: | A total of 461 clinical strains of anaerobes were tested using a broth microdilution test to determine the activity of the combination of ceftriaxone and tazobactam and other antimicrobials against these isolates. Ceftriaxone was combined with tazobactam in ratios of 1:1, 2:1, 4:1, and 8:1 and twofold dilutions of ceftriaxone in constant concentrations to tazobactam of 2, 4, 8, 16, and 32 micrograms/ml. Against beta-lactamase-producing strains of the Bacteroides fragilis group, B. capillosus, and Prevotella species all combinations of ceftriaxone and tazobactam showed enhanced in vitro activity and were eight- to 2048-fold more active than ceftriaxone alone. By comparison ceftriaxone and tazobactam showed superior or equal activity to ampicillin and sulbactam, piperacillin and tazobactam, amoxicillin and clavulanate, ticarcillin and clavulanate, and metronidazole against these same strains. Against beta-lactamase nonproducing strains of Porphyromonas, Fusobacterium, Clostridium, Eubacterium, Peptostreptococcus, and Veillonella parvula the addition of tazobactam produced no appreciable enhanced ceftriaxone activity. Fixed concentrations of tazobactam at 2 and 4 micrograms/ml appear to be most suitable for susceptibility testing and are within the pharmacologic profile of this inhibitor. Pharmacologic and toxicity studies will be needed to define the role of ceftriaxone and tazobactam in infectious diseases. |
| Databáze: | OpenAIRE |
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