Transgenerational transmission of an anticholinergic endophenotype with memory dysfunction
| Autor: | Thomas Arendt, James Wolpers, Martina K. Brückner, Uwe Ueberham, Wolfram Doehner, Lieselotte Praße |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Aging Memory Dysfunction Endophenotypes Offspring Disease Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Alzheimer Disease Pregnancy medicine Animals Dementia Memory impairment Maternal-Fetal Exchange Memory Disorders Ethanol General Neuroscience Cognition medicine.disease Acetylcholine Rats Substance abuse 030104 developmental biology Fetal Alcohol Spectrum Disorders Prenatal Exposure Delayed Effects Endophenotype Female Neurology (clinical) Geriatrics and Gerontology Cognition Disorders Psychology Neuroscience 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Neurobiology of Aging. 51:19-30 |
| ISSN: | 0197-4580 |
| Popis: | Impaired cholinergic neurotransmission associated with cognitive dysfunction occurs in various mental disorders of different etiologies including Alzheimer's disease and postalcoholic dementia and others. To address the question whether there exists a common endophenotype with a defined genetic and/or epigenetic signature causing mental dysfunction in these disorders, we investigated 2 generations of offspring born to alcohol-treated mothers. Here, we show that memory impairment and reduced synthesis of acetylcholine occurs in both F1 (exposed to ethanol in utero) and F2 generation (never been exposed to ethanol). Effects in the F2 generation are most likely consequences of transgenerationally transmitted epigenetic modifications in stem cells induced by alcohol. This clearly documents the role of ancestral history of drug abuse on the brain development of subsequent generations. The results further suggest an epigenetic trait for an anticholinergic endophenotype associated with cognitive dysfunction which might be relevant to our understanding of mental impairment in neurodegenerative disorders such as Alzheimer's disease and related disorders. |
| Databáze: | OpenAIRE |
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