Carcinosarcoma of the Uterus: A Study From the Surveillance Epidemiology and End Result (SEER) Database
| Autor: | Khalida Khaliq, Asad Ullah, Shaikh Hai, Noor Nama, Pete F. Peterson, Furqan Haq, Subhasis Misra, Wazir Akbar, Abdul Waheed, Frederick D Cason, Fernando F Grishko, Joseph Love, Veronica Tucci |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Combination therapy medicine.medical_treatment Uterus carcinosarcoma 030204 cardiovascular system & hematology Gastroenterology uterine cancer seer 03 medical and health sciences 0302 clinical medicine Uterine cancer Internal medicine Carcinosarcoma Epidemiology medicine endometrioid adenocarcinomas business.industry Incidence (epidemiology) General Engineering Odds ratio medicine.disease Radiation therapy medicine.anatomical_structure Oncology General Surgery Obstetrics/Gynecology business 030217 neurology & neurosurgery |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | Background: Uterine cancer (UC) is one of the leading gynecologic neoplastic disorders in the United States (US), of which over 80% are endometrioid adenocarcinomas (EA). In contrast to EA, carcinosarcoma (CS) of the uterus is a sporadic and highly malignant tumor, phylogenetically containing both epithelial and mesenchymal histologic elements. This study sought to analyze demographic, pathological retrospectively, and survival characteristics of a large cohort of CS patients compared to EA patients to identify prognostic factors and treatment approaches that may improve the current clinical management of CS patients. Methods: Demographic and clinical data were abstracted from 88,530 patients diagnosed with uterine malignancy from the Surveillance, Epidemiology, and End Results (SEER) database for 38 years (1973-2010). Extracted variables were analyzed using the Chi-square test, paired t-test, and multivariate analysis, while Kaplan-Meier functions were used to compare survival between groups. Statistical analyses were performed with IBM Statistical Product and Service Solutions (SPSS©), version 20.2 (IBM Corp., Armonk, NY). Results: A total of 3,706 cases of CS comprised 38.2% of uterine sarcomas (n=9,702), and 4.1% of uterine cancers overall (n=88,530). EA made up 88.6% (n=78,481) of all uterine cancers. CS patients presented later in life (68.3±11.5 years) than EA (61.9±12.5 years). 65.2% of CS and 77.8% of EA occurred in Caucasians. The incidence (per million) of EA was higher in Caucasians compared to African-Americans (AA) (41% vs. 26.8%), while the incidence of CS was higher among AA than Caucasians (4% vs. 1.9%, p |
| Databáze: | OpenAIRE |
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