Vaccination against cestode parasites
| Autor: | Michael D. Rickard, Marshall W. Lightowlers |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Protozoan Vaccines
0301 basic medicine Immunology Antibodies Helminth Sheep Diseases 03 medical and health sciences 0302 clinical medicine Immunity medicine Animals Immunology and Allergy Helminths Taeniasis Echinococcus granulosus Vaccines Synthetic Sheep Taenia biology Vaccination Oncosphere Cell Biology biology.organism_classification medicine.disease Virology Metacestode 030104 developmental biology 030215 immunology |
| Zdroj: | Immunology and Cell Biology. 71:443-451 |
| ISSN: | 0818-9641 |
| DOI: | 10.1038/icb.1993.50 |
| Popis: | Cestodes are tapeworm parasites. Infection in the intermediate host with larval (metacestode) parasites causes medically and economically important diseases known as hydatidosis and cysticercosis. Immunization against experimental infection with metacestode parasites has been highly successful, in marked contrast with the relative ineffectiveness of vaccines against infection with most parasitic organisms. High levels of immunity against a challenge infection with taeniid cestode eggs can be stimulated by immunization with extracts of the parasites, particularly with extracts of the oncosphere life-cycle stage. This led to the production of a recombinant antigen vaccine against infection in sheep with the parasite Taenia ovis, the first highly effective, non-living vaccine against a parasitic infection in animals or humans. This paper reviews immunity to the adult and metacestode life-cycle stages of cestode parasites, development and application of the T. ovis vaccine, and prospects for vaccines against other cestode infections. |
| Databáze: | OpenAIRE |
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