Effect of immunization on the development of latent ganglionic infection in mice challenged intravaginally with herpes simplex virus types 1 and 2
| Autor: | Ludmila V. Shavrina Asher, M.Antoinette Walz, Abner Louis Notkins |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
viruses
Avirulent strain Virulence Cross Reactions medicine.disease_cause Antibodies Viral Virus Microbiology Mice Neutralization Tests medicine Animals Simplexvirus Neutralizing antibody Mice Inbred BALB C biology Obstetrics and Gynecology Cross reactions Herpes Simplex Virology Herpes simplex virus Immunization Vagina biology.protein Female Ganglia Antibody Nervous System Diseases |
| Zdroj: | American journal of obstetrics and gynecology. 131(7) |
| ISSN: | 0002-9378 |
| Popis: | Immunization of BALB/c mice with virulent and avirulent strains of HSV-1 resulted in high levels of neutralizing antibody and protected against both the lethal effect of the virus and the development of a latent ganglionic infection when animals were challenged by the intravaginal route. In animals immunized with avirulent strain of HSV-2 and challenged with a high virulent strain of HSV-2, substantial protection against death was observed despite low levels of neutralizing antibody. Nineteen per cent of the survivors, however, developed a latent ganglionic infection. Relatively little protection was observed in mice immunized with HSV-1 and challenged with HSV-2. |
| Databáze: | OpenAIRE |
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