Autoimmunity in hereditary retinal degenerations. II. Clinical studies: antiretinal antibodies and fluorescein angiogram findings
| Autor: | Roberta H. Meyers-Elliott, John R. Heckenlively, Susan M. Chant, Alfred M. Solish |
|---|---|
| Rok vydání: | 1985 |
| Předmět: |
Adult
Male Retinal degeneration Pathology medicine.medical_specialty Cellular immunity Lymphocyte Lymphocyte Activation medicine.disease_cause Retina Immunoglobulin G Autoimmunity Cellular and Molecular Neuroscience chemistry.chemical_compound Antigen Immunity Retinitis pigmentosa medicine Humans Fluorescein Angiography Child Telangiectasia Autoantibodies Immunity Cellular biology medicine.diagnostic_test business.industry Retinal Degeneration Retinal General Medicine medicine.disease Fluorescein angiography Sensory Systems Staining Ophthalmology medicine.anatomical_structure Immunoglobulin M chemistry Immunology biology.protein Female medicine.symptom business Retinitis Pigmentosa Research Article Retinopathy |
| Zdroj: | British Journal of Ophthalmology. 69:758-764 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.69.10.758 |
| Popis: | Testing by indirect immunofluorescence for the detection of antiretinal antibodies and lymphocyte stimulation for cell-mediated immunity to retinal antigens was performed on blood obtained from 59 patients with retinitis pigmentosa (RP) and 29 without RP who had other types of retinal disease. The results from the patients' immunological studies were correlated in a masked fashion with six parameters of the fluorescein angiogram: disc staining, peripapillary oedema, vascular arcade oedema, macular oedema, and focal vascular staining (late phases), and disc telangiectasia (early phases). Significant correlations for both groups together were found for IgG antiretinal antibody reactivity and macular oedema (p less than 0.038) and disc staining (p less than 0.033). The non-RP retinal disease group had more significant correlations, including IgG antiretinal antibody reactivity with vascular arcade oedema (p less than 0.018), disc staining (p less than 0.018), and peripapillary oedema (p less than 0.023); the RP patients had significant correlation with IgG reactivity and arcade oedema (p less than 0.045). With combinations of IgG, IgM, and lymphocyte reactivity various significant correlations were found with the fluorescein angiogram. |
| Databáze: | OpenAIRE |
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