IL-1β polymorphism and expression associated with decreased risk of gastric carcinoma: a case control study in the ethnic Kashmiri population, India
| Autor: | Sameer H. Naqash, Mushtaq A. Siddiqi, Amat Us Samie, Aga Syed Sameer, Shakir Ali, Syed Irtiza |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Pathology Genotype Epidemiology Population Interleukin-1beta India Single-nucleotide polymorphism Biology Gastroenterology Polymorphism Single Nucleotide Asian People Gene Frequency Risk Factors Stomach Neoplasms Internal medicine medicine Odds Ratio Humans Genetic Predisposition to Disease Allele education Alleles education.field_of_study Haplotype Public Health Environmental and Occupational Health Case-control study Odds ratio Middle Aged Oncology Case-Control Studies Immunohistochemistry Female |
| Zdroj: | Asian Pacific journal of cancer prevention : APJCP. 16(5) |
| ISSN: | 2476-762X |
| Popis: | The aim of this research was to investigate the possible association between gastric carcinoma (GC) and polymorphisms of the IL-1β gene in the Kashmiri population using peripheral blood DNA from 150 gastric carcinoma cases and 250 population controls with detailed data for clinicopathological characteristics of the disease. Two SNPs in the IL-1β gene were selected for this study. Expression of IL-1β was studied in 50 gastric carcinoma cases using immunohistochemistry and RT-PCR and then correlated with genotype. The frequency of the IL-1β-511 C allele was significantly higher in the GC case group (53.3%) than in controls (45.4%) with an odds ratio (OR) of 0.73 and a P value of 0.03. Multivariate regression analysis showed associations of gastric carcinoma with mutant form of IL-1β-511 TT (OR 0.309; P value |
| Databáze: | OpenAIRE |
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