Low-toxicity carbon quantum dots derived from gentamicin sulfate to combat antibiotic resistance and eradicate mature biofilms
| Autor: | Weiwei Cao, Peili Li, Gaoke Zhang, Xuedong Gong, Shuai Liu, Xu Yang, Xiaodong Xing |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Staphylococcus aureus
medicine.drug_class Cell Survival Antibiotics Drug resistance Microbial Sensitivity Tests medicine.disease_cause Catalysis Cell Line Mice Antibiotic resistance Quantum Dots Materials Chemistry medicine Animals Humans biology Chemistry Metals and Alloys Biofilm Drug Resistance Microbial General Chemistry 3T3 Cells biology.organism_classification Combinatorial chemistry Carbon Surfaces Coatings and Films Electronic Optical and Magnetic Materials Anti-Bacterial Agents Gentamicin Sulfate HEK293 Cells Biofilms Ceramics and Composites Gentamicins Antibacterial activity Bacteria |
| Zdroj: | Chemical communications (Cambridge, England). 56(15) |
| ISSN: | 1364-548X |
| Popis: | Carbon quantum dots derived from gentamicin sulfate are directly developed by facile calcination at different temperatures. A promising nanomaterial, CQD180, even shows a much superior antibacterial activity compared with the antibiotic counterpart and low drug resistance, by preserving the active structure of the starting materials and providing an additional antibacterial mode arising from the positive charge surface and induced reactive oxygen species simultaneously. Moreover, CQD180 can effectively disrupt mature Staphylococcus aureus biofilm and selectively eliminate bacteria over mammalian cells. |
| Databáze: | OpenAIRE |
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