Synthetic Antimicrobial Polymers in Combination Therapy: Tackling Antibiotic Resistance
| Autor: | Cyrille Boyer, Edgar H. H. Wong, Rashin Namivandi-Zangeneh |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
chemistry.chemical_classification Combination therapy Polymers medicine.drug_class 030106 microbiology Antimicrobial peptides Antibiotics Polymer Antimicrobial Combinatorial chemistry Anti-Bacterial Agents 3. Good health Penicillin 03 medical and health sciences 030104 developmental biology Infectious Diseases Multidrug resistant bacteria Antibiotic resistance Anti-Infective Agents chemistry Drug Resistance Multiple Bacterial medicine medicine.drug |
| Zdroj: | ACS Infectious Diseases. 7:215-253 |
| ISSN: | 2373-8227 |
| DOI: | 10.1021/acsinfecdis.0c00635 |
| Popis: | Antibiotic resistance is a critical global healthcare issue that urgently needs new effective solutions. While small molecule antibiotics have been safeguarding us for nearly a century since the discovery of penicillin by Alexander Fleming, the emergence of a new class of antimicrobials in the form of synthetic antimicrobial polymers, which was driven by the advances in controlled polymerization techniques and the desire to mimic naturally occurring antimicrobial peptides, could play a key role in fighting multidrug resistant bacteria in the near future. By harnessing the ability to control chemical and structural properties of polymers almost at will, synthetic antimicrobial polymers can be strategically utilized in combination therapy with various antimicrobial coagents in different formats to yield more potent (synergistic) outcomes. In this review, we present a short summary of the different combination therapies involving synthetic antimicrobial polymers, focusing on their combinations with nitric oxide, antibiotics, essential oils, and metal- and carbon-based inorganics. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|