Comparison of gas chromatography-mass spectrometry and gas chromatography-tandem mass spectrometry with electron ionization for determination of N-nitrosamines in environmental water

Autor: Lunshan Zhao, Xiao-Shui Li, Shihua Qi, Wenwen Chen, Xiuli Liu, Xuetao Zhu, Huanfang Huang, Yuan Zhang, Kuang Cen, Jiang Xiaoyu
Rok vydání: 2017
Předmět:
China
Spectrometry
Mass
Electrospray Ionization
Nitrosamines
Environmental Engineering
Health
Toxicology and Mutagenesis
010501 environmental sciences
Mass spectrometry
01 natural sciences
Gas Chromatography-Mass Spectrometry
chemistry.chemical_compound
Rivers
Tandem Mass Spectrometry
Environmental Chemistry
Ponds
Groundwater
Electron ionization
0105 earth and related environmental sciences
Detection limit
Chromatography
Gas Chromatography/Tandem Mass Spectrometry
Solid Phase Extraction
010401 analytical chemistry
Selected reaction monitoring
Public Health
Environmental and Occupational Health
General Medicine
General Chemistry
Contamination
Pollution
0104 chemical sciences
chemistry
Nitrosamine
Environmental chemistry
Gas chromatography–mass spectrometry
Water Pollutants
Chemical
Environmental Monitoring
Zdroj: Chemosphere. 168:1400-1410
ISSN: 0045-6535
DOI: 10.1016/j.chemosphere.2016.11.109
Popis: N -nitrosamines are trace organic contaminants of environmental concern when present in groundwater and river water due to their potent carcinogenicity. Therefore, N -nitrosamine analysis is increasingly in demand. Gas chromatography-mass spectrometry (GC-MS) and GC-tandem mass spectrometry (GC-MS/MS), both with electron ionization (EI), were compared for analysis of nine N -nitrosamines extracted from environmental water matrices. A total of 20 fishpond water, river water, and groundwater samples from Sihui and Shunde, China were collected for a survey of N -nitrosamine concentrations in real water samples. Various solid-phase extraction (SPE) conditions and GC conditions were first examined for the pre-concentration and separation steps. The analysis of N -nitrosamines in environmental waters demonstrated that their quantification with GC-MS poses a challenge due to the occurrence of co-eluting interferences. Conversely, the use of GC-MS/MS increased selectivity because of the fragmentation generated from precursor ions in the ‘multiple reaction monitoring’ (MRM) mode, which is expected to extract target analytes from the environmental water matrix. Thus, the high performance of GC-MS/MS with EI was used to quantify nine N -nitrosamines in environmental waters with detection limits of 1.1–3.1 ng L −1 . N -nitrosodimethylamine (NDMA) concentrations were in the range of N.D. to 258 ng L −1 . Furthermore, other N -nitrosamines, except N -nitrosomethylethylamine (NMEA), N -nitroso-di- n -propylamine (NDPA) and N -nitrosopiperidine (NPIP), were also detected. Our findings suggest that GC-MS/MS with EI would be widely applicable in identifying N -nitrosamines in environmental waters and can be used for routine monitoring of these chemicals.
Databáze: OpenAIRE
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