Prevalence of celiac disease among blood donors in São Paulo: the most populated city in Brazil
| Autor: | lêda Nishitokukado, Maria Elizabeth Rossi da Silva, Clarice Pires Abrantes-Lemos, Marília Lage Alencar, Dalton de Alencar Fischer Chamone, André Zonetti de Arruda Leite, Carmen Lucia Ortiz-Agostinho, Daniel Giannella-Neto, Aderson Omar Mourão Cintra Damião, Aytan Miranda Sipahi, Thales de Brito |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Immunoglobulin A medicine.medical_specialty Adolescent Population Ethnic group Blood Donors Disease Human leukocyte antigen Young Adult Internal medicine Anti-transglutaminase antibody parasitic diseases medicine Prevalence Humans Celiac disease Enteropathy Cities Young adult education Aged education.field_of_study lcsh:R5-920 Transglutaminases biology business.industry Racial Groups Anti-endomysium antibody General Medicine Blood center Clinical Science Middle Aged medicine.disease Endomysium medicine.anatomical_structure Immunology biology.protein Blood Banks Female Epidemiologic Methods business lcsh:Medicine (General) Brazil |
| Zdroj: | Clinics, Vol 67, Iss 9, Pp 1013-1018 (2012) Clinics Clinics, Volume: 67, Issue: 9, Pages: 1013-1018, Published: SEP 2012 Clinics; v. 67 n. 9 (2012); 1013-1018 Clinics; Vol. 67 Núm. 9 (2012); 1013-1018 Clinics; Vol. 67 No. 9 (2012); 1013-1018 Universidade de São Paulo (USP) instacron:USP |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVE: Celiac disease is a permanent enteropathy caused by the ingestion of gluten, which leads to an immune-mediated inflammation of the small intestine mucosa. The prevalence of celiac disease varies among different nations and ethnic backgrounds, and its diversity is determined by genetic and environmental factors. São Paulo city is one of the largest cities in the world, with a vast population and an important history of internal migratory flow from other Brazilian regions, as well as immigration from other, primarily European, countries, resulting in significant miscegenation. The aim of the present study was to estimate the prevalence of adults with undiagnosed celiac disease among blood donors of São Paulo by collecting information on the ancestry of the population studied. METHODS: The prevalence of celiac disease was assessed by screening for positive IgA transglutaminase and IgA endomysium antibodies in 4,000 donors (volunteers) in the Fundação Pró-Sangue Blood Center of São Paulo, São Paulo, Brazil. The antibody-positive subjects were asked to undergo a small bowel biopsy. RESULTS: Of the 4,000 subjects, twenty-four had positive tests, although both antibody tests were not always concordant. For example, ten subjects were positive for IgA tissue transglutaminase only. In twenty-one positive patients, duodenal biopsies were performed, and the diagnosis of celiac disease was confirmed in fourteen patients (Marsh criteria modified by Oberhuber). In this group, 67% claimed to have European ancestry, mainly from Italy, Portugal and Spain. CONCLUSION: The prevalence of celiac disease is at least 1:286 among supposedly healthy blood bank volunteers in São Paulo, Brazil. |
| Databáze: | OpenAIRE |
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