A pharmacokinetic study of the active metabolite of nabumetone in young healthy subjects and older arthritis patients
| Autor: | D. C. Kill, M. C. Chellingsworth, A. R. Thawley, R. Jubb, M. J. Kendall, N. A. Undre |
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| Rok vydání: | 1989 |
| Předmět: |
Adult
Male Aging medicine.medical_specialty Time Factors Adolescent Nabumetone Metabolite Arthritis Gastroenterology Naphthaleneacetic Acids Arthritis Rheumatoid chemistry.chemical_compound Pharmacokinetics Oral administration Internal medicine Osteoarthritis medicine Humans Pharmacology (medical) Young adult Active metabolite Aged Aged 80 and over Pharmacology business.industry Anti-Inflammatory Agents Non-Steroidal General Medicine Middle Aged medicine.disease Butanones Endocrinology chemistry Rheumatoid arthritis Female business medicine.drug |
| Zdroj: | European Journal of Clinical Pharmacology. 36:299-305 |
| ISSN: | 1432-1041 0031-6970 |
| DOI: | 10.1007/bf00558163 |
| Popis: | We have performed a detailed pharmacokinetic study of the plasma concentrations of the major active metabolite of nabumetone, 6-methoxy-2-naphthylacetic acid (6 MNA), attained after a single dose and during chronic administration comparing the results of a group of young healthy volunteers with those of a group of elderly arthritic patients. The latter had higher peak plasma concentrations of 6 MNA and slower rates of elimination but there is no tendency for the drug to accumulate unpredictably in the old. Disease activity also influences plasma concentration, those with more active disease, and lower serum albumin concentrations had lower AUC values. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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