Selenium, apoptosis, and colorectal adenomas
| Autor: | Robert S. Sandler, Charles Poole, Robert C. Millikan, Jessie A. Satia, Alexandra Connelly-Frost, Lawrence L. Kupper |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adenoma
Adult Male Programmed cell death medicine.medical_specialty Epidemiology chemistry.chemical_element Colonoscopy Apoptosis Colorectal adenoma Gastroenterology Risk Assessment Sensitivity and Specificity Selenium Age Distribution Reference Values Internal medicine medicine Biomarkers Tumor Prevalence Humans Sex Distribution Aged Neoplasm Staging Probability Aged 80 and over medicine.diagnostic_test business.industry Biopsy Needle food and beverages Cancer Middle Aged medicine.disease Micronutrient Prognosis Immunohistochemistry Endocrinology Cross-Sectional Studies Oncology chemistry Tumor Markers Biological Linear Models Population study Female business Colorectal Neoplasms |
| Zdroj: | Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 15(3) |
| ISSN: | 1055-9965 |
| Popis: | Dietary modulation of carcinogenesis-related pathwaysDietary item or component studied:seleniumPathways studied:apoptosisStudy type (in vitro, animals, humans): humansStudy design (if human):cross-sectional studyStudy size (if human):803 participantsTissue/biological material/sample size: serum, 2 colon biopsiesMode of exposure (if in vivo) (acute, chronic, root of exposure):dietary & lifestyle questionnairesImpact on pathway (including dose-response):for 50-120 μgr/l selenium Pe~0.5-0.3For selenium 120-160 μgr/l Pe~0.4for selenium140μgr/l) associated with decreased prevalence of high apoptosis compared to low selenium levels(2.76 cells per crypt) were not strongly related, but results collectively suggested a roughly inverse association. CONCLUSIONS: High selenium was associated with a reduced prevalence of colorectal adenomas. Apoptosis, however, did not seem to be the mechanism by which selenium was related to adenoma prevalence in our data. |
| Databáze: | OpenAIRE |
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