External Application of Apo-9'-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis
| Autor: | Min-Chull Na, Na-Jin Kang, Weon-Jong Yoon, Hee-Kyoung Kang, Mi-Hee Ko, Nam-Ho Lee, Sejin Kim, Young Sang Koh, Eun-Sook Yoo, Sang Chul Han, Jin-Won Hyun |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis Inflammation Apo-9′-fucoxanthinone Toxicology Immunoglobulin E 2 4-Dinitrochlorobenzene 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Edema medicine 2 4-Dinitrochlorobenzene Atopic dermatitis biology business.industry Ionomycin medicine.disease 030104 developmental biology chemistry 030220 oncology & carcinogenesis Immunology biology.protein Phorbol Phorbol 12-myristate 13-acetate Original Article Tumor necrosis factor alpha medicine.symptom business |
| Zdroj: | Toxicological Research |
| ISSN: | 2234-2753 1976-8257 |
| DOI: | 10.5487/tr.2016.32.2.109 |
| Popis: | Allergic skin inflammation such as atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. The anti-inflammatory effects of Apo-9'-fucoxanthinone, isolated from Sargassum muticum, have been described in many diseases, but the mechanism by which it modulates the immune system is poorly understood. In this study, the ability of Apo-9'-fucoxanthinone to suppress allergic reactions was investigated using a mouse model of atopic dermatitis. The Apo-9'-fucoxanthinone-treated group showed significantly decreased immunoglobulin E in serum. Also, Apo-9'-fucoxanthinone treatment resulted in a smaller lymph node size with reduced the thickness and length compared to the induction group. In addition, Apo-9'-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes. These results suggest that Apo-9'-fucoxanthinone may be a useful therapeutic strategy for treating chronic inflammatory diseases. |
| Databáze: | OpenAIRE |
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