Interleukin-17 expression in the human placenta
| Autor: | Pannika R. Niumsup, Puntharee Butkhamchot, P. Tatiwat, S. Sritippayawan, Sutatip Pongcharoen, S. Kunngurn, J. Somran, Roger F. Searle, P. Chanchan |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Placenta Gene Expression Syncytiotrophoblasts Biology Pregnancy Proteins Proinflammatory cytokine Neovascularization Pregnancy Internal medicine medicine Humans RNA Messenger Cells Cultured Interleukin-17 Obstetrics and Gynecology Trophoblast Interleukin medicine.disease medicine.anatomical_structure Endocrinology Reproductive Medicine embryonic structures Female Interleukin 17 medicine.symptom Developmental Biology |
| Zdroj: | Placenta. 28(1) |
| ISSN: | 0143-4004 |
| Popis: | Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the fetoplacental unit, the expression of IL-17 mRNA and protein in human placental tissues was investigated. IL-17 mRNA was expressed by purified cytokeratin-positive term placental trophoblast cells, HLA-G+ extravillous trophoblast cells and placental macrophages (Hofbauer cells). IL-17 localized in both cyto- and syncytiotrophoblasts of normal term pregnancy, spontaneous miscarriage and in molar pregnancy. In spontaneous miscarriage and molar pregnancy extravillous trophoblast cells were consistently immunoreactive for IL-17. IL-17 expression in human placenta may play a key role in angiogenesis and/or immunoregulation in the establishment of pregnancy. |
| Databáze: | OpenAIRE |
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