Vancomycin and oxacillin synergy for methicillin-resistant staphylococci
| Autor: | Richard A. Venezia, Beth E. Domaracki, Ann M. Evans |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Meticillin
Micrococcaceae Time Factors medicine.drug_class Staphylococcus Antibiotics Microbial Sensitivity Tests medicine.disease_cause Microbiology Vancomycin medicine Pharmacology (medical) Antibacterial agent Oxacillin Pharmacology biology business.industry Drug Synergism biochemical phenomena metabolism and nutrition biology.organism_classification bacterial infections and mycoses Glycopeptide Infectious Diseases Staphylococcus aureus Susceptibility Drug Therapy Combination Methicillin Resistance business medicine.drug |
| Zdroj: | Antimicrobial agents and chemotherapy. 44(5) |
| ISSN: | 0066-4804 |
| Popis: | An increase in oxacillin activity was observed against methicillin-resistant coagulase-negative staphylococci (MRCNS) and methicillin-resistant Staphylococcus aureus (MRSA) in the presence of a sub-MIC of vancomycin. Vancomycin and oxacillin were synergistic against 14 of 21 strains of MRCNS and MRSA. A pattern of enhanced killing was also supported by time-kill studies. These results suggest that combinations of sub-MICs of vancomycin and oxacillin may have therapeutic benefits against methicillin-resistant staphylococci. |
| Databáze: | OpenAIRE |
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