Oral pharmacokinetics of cyclosporin in patients with primary biliary Cirrhosis and patients with skin diseases

Autor: R. Beukers, S. De Rave, J. W. O. Van Den Berg, S.W. Schalm
Rok vydání: 2007
Předmět:
Zdroj: Alimentary Pharmacology & Therapeutics. 6:459-468
ISSN: 1365-2036
0269-2813
DOI: 10.1111/j.1365-2036.1992.tb00559.x
Popis: SUMMARY The pharmacokinetics of cyclosporin after oral administration were studied in seven patients with non-end stage primary biliary cirrhosis (PBC) without previous cyclosporin treatment (Group I), a control group of nine patients with skin diseases (mainly psoriasis; Group II) and six patients with PBC after prolonged cyclosporin treatment (Group III). Whole blood concentrations of cyclosporin were measured using a nonspecific (N) radioimmunoassay (RIA) and — in a majority of the cases—also by a RIA specific (S) for the parent drug. No difference in cyclosporin absorption was observed between patients with PBC and those with a skin disease. The mean values for the area under the blood concentration-time curve for the first 6 h after the test dose (AUC0-6) and the maximal blood concentrations (Cmax) were significantly higher for Group I compared with Group II patients (P= 0.007 and 0.03, respectively), but the time to maximal blood concentrations (tc, max) did not differ. There was a trend toward higher mean AUC0-6 (P= 0.08) and Cmax (P= 0.08) values for Group III compared with Group I patients. Tc, max values were not influenced by prolonged cyclosporin treatment. The ratio of cyclosporin whole blood concentrations measured by the non-specific and specific RIA'S (N/S ratio) increased with time without obvious differences between the three groups. These data suggest that cyclosporin absorption and its biotransformation in the liver are not impaired in patients with non-end stage PBC and that neither is affected by prolonged treatment.
Databáze: OpenAIRE
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