Weight-based thyroid dosing vs fixed dosing during pregnancy for subclinical hypothyroidism: A retrospective cohort study
| Autor: | Afshan Zahedi, Balsam Saeed Bohlega, George Tomlinson, Denice S. Feig |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Pediatrics Endocrinology Diabetes and Metabolism Thyrotropin 030209 endocrinology & metabolism Logistic regression 03 medical and health sciences 0302 clinical medicine Endocrinology Hypothyroidism Pregnancy Internal medicine medicine Humans Dosing Subclinical infection Retrospective Studies business.industry Thyroid Gestational age Retrospective cohort study medicine.disease Pregnancy Complications Thyroxine medicine.anatomical_structure 030220 oncology & carcinogenesis Female business Weight based dosing |
| Zdroj: | Clinical endocrinologyREFERENCES. 96(2) |
| ISSN: | 1365-2265 |
| Popis: | OBJECTIVE Thyroid hormones play a crucial role in foetal growth and neurocognitive development. Our aim was to compare a weight-based dosing method of starting thyroxine to a fixed-dose method in newly diagnosed women with subclinical hypothyroidism during pregnancy. DESIGN We performed a retrospective cohort study of consecutive women with newly diagnosed subclinical hypothyroidism during pregnancy seen at Mount Sinai Hospital and Women's College Hospital, Toronto, Canada 2015-2018. PATIENTS We identified women that were treated based on pre-pregnancy weight and those that were given a fixed dose of 50 mcg/day. MEASUREMENTS The percent of women who reached the target TSH of |
| Databáze: | OpenAIRE |
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