n−3 polyunsaturated fatty acids and coronary thrombosis
| Autor: | S. D. Kristensen, A. M. Bach Iversen, E. B. Schmidt |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Blood Platelets
medicine.medical_specialty Clinical chemistry medicine.medical_treatment Greenland Myocardial Infarction Biochemistry Coronary thrombosis Internal medicine Fatty Acids Omega-3 Antithrombotic Fibrinolysis medicine Animals Humans Platelet Myocardial infarction Blood Coagulation chemistry.chemical_classification business.industry Coronary Thrombosis Organic Chemistry Cell Biology medicine.disease Thrombosis Endocrinology chemistry Inuit business Polyunsaturated fatty acid |
| Zdroj: | Kristensen, S D, Iversen, A M B & Schmidt, E B 2001, ' n-3 Polyunsaturated Fatty Acids and Coronary Thrombosis ', Lipids, vol. 36, pp. 79-82 . |
| ISSN: | 1558-9307 0024-4201 |
| DOI: | 10.1007/s11745-001-0686-8 |
| Popis: | Studies of Greenland Eskimos showed that a very high intake of marine n-3 fatty acids markedly inhibited platelet reactivity and suggested that intake of these fatty acids might prevent coronary thrombosis. Later studies with lower, more practical doses of n-3 fatty acids also have shown a platelet inhibitory effect of n-3 fatty acids, albeit fairly marginal. Furthermore, n-3 fatty acids have little effect on measures of blood coagulability and may slightly decrease fibrinolysis. In animal models, n-3 fatty acids often have been shown to inhibit thrombosis, but again the doses have tended to be very high. Finally, there has been little effect of (low-dose) n-3 fatty acids in clinical trials in humans on the incidence of myocardial infarction. Overall, there is little evidence for a major antithrombotic effect of practical doses of n-3 fatty acids on coronary thrombosis. This does not exclude a beneficial effect of n-3 fatty acids on coronary heart disease as suggested from clinical trials, but the major effect may be antiarrhythmic rather than antithrombotic. |
| Databáze: | OpenAIRE |
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