Abnormal sensorimotor integration is related to disease severity in Parkinson's disease: a TMS study
| Autor: | Stefano Tamburin, Piergiorgio Lochner, Giampietro Zanette, Antonio Fiaschi, D Idone, Paolo Manganotti |
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| Přispěvatelé: | Tamburin, S., Fiaschi, A., Idone, D., Lochner, P., Manganotti, Paolo, Zanette, G. |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
Parkinson's disease medicine.medical_treatment Neurological disorder Disease bradykinesia sensorimotor integration motor evoked potentials digital nerve stimulation transcranial magnetic stimulation Severity of Illness Index Feedback Central nervous system disease Magnetics Degenerative disease Motor system medicine Humans Evoked potential Gait Disorders Neurologic Aged Aged 80 and over Skull Parkinson Disease Middle Aged Evoked Potentials Motor medicine.disease Transcranial magnetic stimulation Neurology Female Neurology (clinical) Psychology Neuroscience |
| Popis: | Hyperexcitability of the motor system has been reported in Parkinson's disease (PD). We evaluate how cutaneous afferents modulate motor excitability in PD patients and whether abnormal modulation is correlated to parkinsonian symptoms. Digital stimulation causes abnormal enhancement of motor responses in patients. This effect may be one of the features of motor hyperexcitability in PD. Cutaneomotor hyperexcitability correlates with clinical scores, suggesting that abnormal processing of cutaneous inputs might contribute to the pathogenesis of parkinsonian symptoms. |
| Databáze: | OpenAIRE |
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