Effects of Low-to-Moderate Doses of Anabolic Steroids on Lipid Profile and Muscle Hypertrophy in Resistance Training Practitioners: A Systematic Review with Meta-Analysis
| Autor: | Mário César Carvalho Tenório, Flávia Valladares, Luis C. L. Correia, Cloud Kennedy Couto de Sá, Marcelo dos Santos Guimarães Júnior, Cláudio Luiz da Silva Lima Paz |
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| Rok vydání: | 2021 |
| Předmět: |
Esthetics
medicine.diagnostic_test Anabolism testosterone Congeners business.industry Resistance Training 020206 networking & telecommunications 02 engineering and technology Bioinformatics Affect (psychology) Muscle hypertrophy Young Adult Receptors Androgen Meta-analysis 0202 electrical engineering electronic engineering information engineering Medicine 020201 artificial intelligence & image processing Young adult business Lipid profile Adverse effect Testosterone Congeners |
| Zdroj: | International Journal of Cardiovascular Sciences, Volume: 34, Issue: 5, Pages: 531-541, Published: 12 MAY 2021 International Journal of Cardiovascular Sciences v.34 n.5 2021 International Journal of Cardiovascular Sciences Sociedade Brasileira de Cardiologia (SBC) instacron:SBC |
| ISSN: | 2359-5647 2359-4802 |
| DOI: | 10.36660/ijcs.20200107 |
| Popis: | Background: The use of androgenic anabolic steroids (AAS) is prevalent among young bodybuilders, motivated by aesthetic results. Although the medical community condemns this practice for its potential deleterious effect, we must recognize the need for more scientific research on the likelihood and magnitude of the adverse events. Objective: To evaluate whether high-quality, scientific evidence supports that AAS negatively affect lipid profile and promote muscle hypertrophy in resistance training practitioners. Methods: A systematic review of the literature of randomized clinical trials was conducted in the PubMed / Medline, Scielo and Science direct databases. The searches were conducted by two independent researchers by June 2018. A significance level of 5% was considered in the analysis. Results: Six clinical trials involving 170 resistance training practitioners were included. A significant heterogeneity was found in studies evaluating the effects of AAS on lipid profile and muscle hypertrophy (I² = 97, 95 and 91%, respectively), with no significant effects on HDL-cholesterol (-5.62mg/dL, 95%CI −12.10, 0.86, p= 0.09), LDL-cholesterol (7.76 mg/dL, 95%CI −9.70, 25.23, p= 0.57) and muscle hypertrophy (2.44kg 95%CI 0.02, 4.86, p=0.05). Conclusion: Current evidence does not support that low-to-moderate doses of AAS cause serious negative effects on lipid profile or promote muscle hypertrophy in resistance training practitioners. |
| Databáze: | OpenAIRE |
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