Subicular lesions cause dendritic atrophy in CA1 and CA3 pyramidal neurons of the rat hippocampus
| Autor: | Trichur R. Raju, Govindaiah, B.L Meti, T. R. Laxmi, B. S. Shankaranarayana Rao |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Microinjections Central nervous system Hippocampus Dendrite Cell Count Biology Hippocampal formation Lesion chemistry.chemical_compound Atrophy Oxazines medicine Animals Rats Wistar Ibotenic Acid Analysis of Variance General Neuroscience Pyramidal Cells Subiculum Dendrites medicine.disease Benzoxazines Rats medicine.anatomical_structure nervous system chemistry medicine.symptom Neuroscience Ibotenic acid |
| Zdroj: | Neuroscience. 102(2) |
| ISSN: | 0306-4522 |
| Popis: | The subiculum is a major source of output projections from hippocampus to cortical and subcortical regions. Our previous studies have demonstrated the selective loss of CA1 pyramidal neurons of the hippocampus, and operant and spatial learning impairment in subicular lesioned rats [Govindaiah et al. (1997) Brain Res. 745, 121-126; Laxmi et al. (1999) Brain Res. 816, 245-148]. In the present study, the effect of ibotenate lesions of the subiculum on the dendritic morphology of CA1 and CA3 pyramidal neurons of the hippocampus was investigated in 30-day-old male Wistar rats. The ventral subiculum was lesioned bilaterally with multiple injections of ibotenic acid, stereotaxically. The dendritic branching points and intersections were studied in apical and basal dendrites up to 320 and 160 microm, respectively, in Golgi-impregnated CA1 and CA3 pyramidal neurons of the hippocampus. The results revealed a significant (P |
| Databáze: | OpenAIRE |
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