The efficiency of the brain connectome is associated with cerebrovascular reactivity in persons with white matter hyperintensities
| Autor: | David J. Mikulis, Joseph A. Fisher, Kevin Sam, Julien Poublanc, William Reginold, Adrian P. Crawley |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty 050105 experimental psychology White matter 03 medical and health sciences 0302 clinical medicine Cerebrovascular reactivity Internal medicine Connectome medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Gray Matter Research Articles Aged Aged 80 and over Radiological and Ultrasound Technology business.industry 05 social sciences Leukoaraiosis Brain Middle Aged White Matter Hyperintensity Diffusion Tensor Imaging medicine.anatomical_structure Neurology Cerebrovascular Circulation Cardiology Female Neurology (clinical) Anatomy business Graph theory analysis 030217 neurology & neurosurgery Diffusion MRI Tractography |
| Zdroj: | Hum Brain Mapp |
| ISSN: | 1097-0193 1065-9471 |
| Popis: | The purpose of this study was to determine the relationship between the organization of the brain connectome and cerebrovascular reactivity (CVR) in persons with white matter hyperintensities. Diffusion tensor and CVR mapping 3T MRI scans were acquired in 31 participants with white matter hyperintensities. In each participant, the connectome was assessed by reconstructing all white matter tracts with tractography and segmenting the whole brain into multiple regions. Graph theory analysis was performed to quantify how effectively tracts connected brain regions by measuring the global and local efficiency of the connectome. CVR in white matter and gray matter was correlated with the global and local efficiency of the connectome, while adjusting for age, gender, and gray matter volume. For comparison, white matter hyperintensity volume was also correlated with global and local efficiency. White matter CVR was positively correlated with the global efficiency (coefficient: 23.3, p = .005) and local efficiency (coefficient: 2850, p = .004) of the connectome. Gray matter CVR was positively correlated with the global efficiency (coefficient: 21.3, p |
| Databáze: | OpenAIRE |
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