The P-selectin gene Pro715 allele and low levels of soluble P-selectin are associated with reduced P2Y12 adenosine diphosphate receptor reactivity in clopidogrel-treated patients
| Autor: | Renate Koppensteiner, Cihan Ay, Thomas Gremmel, Sabine Steiner, Daniela Seidinger, Christine Mannhalter, Simon Panzer, Christoph W. Kopp |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty P2Y receptor Ticlopidine Proline P-selectin chemistry.chemical_compound P2Y12 Internal medicine medicine Humans Reactivity (chemistry) Prospective Studies Allele Receptor Alleles Polymorphism Genetic Chemistry Angioplasty Middle Aged Clopidogrel Molecular biology Receptors Purinergic P2Y12 P-Selectin Adenosine diphosphate Endocrinology Purinergic P2Y Receptor Antagonists Female Cardiology and Cardiovascular Medicine Platelet Aggregation Inhibitors medicine.drug |
| Zdroj: | Atherosclerosis. 217:135-138 |
| ISSN: | 0021-9150 |
| Popis: | To investigate the interrelation between the P-selectin gene (SELP) Pro715 allele, P2Y12 adenosine diphosphate (ADP) receptor reactivity and levels of soluble P-selectin (sP-selectin) in clopidogrel treated patients.The Pro715 allele within SELP was tested by allele specific PCR, sP-selectin was determined by ELISA, and P2Y12 receptor reactivity was analyzed by the VASP assay in 156 patients after angioplasty and stenting.Carriers of the SELP Pro715 allele had significantly lower levels of sP-selectin and P2Y12 receptor reactivity, and high on-treatment residual P2Y12 receptor reactivity (HRPR) was significantly less frequent compared to non-carriers (both p0.05). Further, patients within the lowest quartile of sP-selectin had significantly lower reactivity values and also less often HRPR compared to patients with higher sP-selectin (both p0.01).The SELP Pro715 allele is linked to low levels of sP-selectin, and both are associated with decreased P2Y12 ADP receptor reactivity in patients on clopidogrel therapy. |
| Databáze: | OpenAIRE |
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