New trends in the pharmacological intervention of PPARs in obesity: Role of natural and synthetic compounds_
| Autor: | Ana Sanches-Silva, Luciano Saso, Sethuraman Sathya, Maria Daglia, Sylwia Talarek, Kasi Pandima Devi, Seyed Mohammad Nabavi, Silvia Tejada, Ahmad Reza Dehpour, Samira Shirooie, Listos Joanna, Suowen Xu, Maciej Banach, Seyed Fazel Nabavi, Antoni Sureda |
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| Přispěvatelé: | Nabavi, Seyed Mohammad, Devi, Kasi Pandima, Sathya, Sethuraman, Sanches-Silva, Ana, Joanna, Listo, Talarek, Sylwia, Xu, Suowen, Daglia, Maria, Nabavi, Seyed Fazel, Shirooie, Samira, Sureda, Antoni, Tejada, Silvia, Banach, Maciej, Dehpour, Ahmad Reza, Saso, Luciano |
| Rok vydání: | 2020 |
| Předmět: |
Peroxisome Proliferator-Activated Receptors
Population Receptors Cytoplasmic and Nuclear Adipose tissue Peroxisome proliferator-activated receptor Biology Ligands Cardiovascular Bioinformatics 01 natural sciences Biochemistry PPAR agonist Peroxisome proliferator–activated receptors 03 medical and health sciences Drug Discovery medicine Humans Obesity 0101 mathematics education Receptor Transcription factor 030304 developmental biology Pharmacology chemistry.chemical_classification 0303 health sciences education.field_of_study Organic Chemistry medicine.disease Endogenous and exogenous ligand 010101 applied mathematics chemistry Nuclear receptor Molecular Medicine Natural and synthetic agonists Transcription Factors |
| Zdroj: | Current Medicinal Chemistry. 28 |
| ISSN: | 0929-8673 |
| DOI: | 10.2174/1570162x18666201123114934 |
| Popis: | Obesity is a major health concern for a growing fraction of the population, with the prevalence of obesity and its related metabolic disorders not being fully understood. Over the last decade, many attempts have been undertaken to understand the mechanisms at the basis of this condition, in which the accumulation of fat occurring in adipose tissue, leads to the pathogenesis of obesity related disorders. Among the most recent studies, those on Peroxisome Proliferator Activated Receptors (PPARs) revealed that these nuclear receptor proteins acting as transcription factors, among others, regulate the expression of genes involved in energy, lipid, and glucose metabolisms, and chronic inflammation. The three different isotypes of PPARs, with different tissue expression and ligand binding specificity, exert similar or overlapping functions directly or indirectly linked to obesity. In this study, we reviewed the available scientific reports concerning the PPARs structure and functions, especially in obesity, considering both natural and synthetic ligands and their role in the therapy of obesity and obesity-associated disorders. In the whole, the collected data show that there are both natural and synthetic compounds that show beneficial promising activity as PPAR agonists in chronic diseases related to obesity. |
| Databáze: | OpenAIRE |
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