Structure of Kaurane-Type Diterpenes fromParinari spruceiand their Potential Anticancer Activity
| Autor: | Steven M. Swanson, Hee Byung Chai, Annahil Armenise, Jeannette Mendez, Alessandra Braca, Nunziatina De Tommasi, Ivano Morelli, Qiuwen Mi, A. Douglas Kinghorn |
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| Rok vydání: | 2004 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Pharmaceutical Science Pharmacognosy Analytical Chemistry chemistry.chemical_compound In vivo Cell Line Tumor Drug Discovery LNCaP Humans Picea Cytotoxicity Pharmacology Natural product biology Plant Extracts Organic Chemistry biology.organism_classification Antineoplastic Agents Phytogenic Parinari In vitro Plant Leaves Complementary and alternative medicine chemistry Molecular Medicine Diterpene Diterpenes Kaurane Phytotherapy |
| Zdroj: | Planta Medica. 70:540-550 |
| ISSN: | 1439-0221 0032-0943 |
| DOI: | 10.1055/s-2004-827155 |
| Popis: | Twenty-three kaurane-type diterpenes 1 - 23, including twenty new natural products 1 - 20, have been isolated from the leaves of Parinari sprucei and their structures elucidated by spectroscopic and chemical analysis. The isolated compounds were tested for their cytotoxic activity towards a panel of cancer cell lines. Compounds 9 and 10 showed activity against all cell lines with ED (50) values in the range of 10 - 20 microg/mL. The previously known 13-hydroxy-15-oxozoapatlin 21 was evaluated in an in vivo hollow fiber test, and found to be active with KB and LNCaP cells at the concentrations used. |
| Databáze: | OpenAIRE |
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