BMD-based assessment of local porosity in human femoral cortical bone
| Autor: | Robert Wendlandt, Kay Raum, Caroline E. Wyers, Johannes Schneider, Reinhard Barkmann, Gianluca Iori, Vantte Kilappa, Peter Varga, Melanie Gräsel, Frans Heyer, J. van den Bergh |
|---|---|
| Přispěvatelé: | Interne Geneeskunde, Promovendi NTM, RS: NUTRIM - R3 - Respiratory & Age-related Health |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Histology Materials science Bone density Physiology Endocrinology Diabetes and Metabolism Cortical bone Microscopy Acoustic Scanning Acoustic Microscopy 030209 endocrinology & metabolism Bone tissue DISTAL RADIUS 03 medical and health sciences 0302 clinical medicine Bone Density medicine Humans Femur COMPUTED-TOMOGRAPHY Quantitative computed tomography Porosity Image registration Aged Aged 80 and over Bone mineral HR-pQCT medicine.diagnostic_test ELASTICITY HUMAN FEMUR IN-VITRO COMPACT-BONE 030104 developmental biology medicine.anatomical_structure SCANNING ACOUSTIC MICROSCOPY QUANTITATIVE ULTRASOUND Female MINERAL DENSITY HIGH-RESOLUTION Biomedical engineering |
| Zdroj: | Bone, 114, 50-61. Elsevier Science |
| ISSN: | 8756-3282 |
| DOI: | 10.1016/j.bone.2018.05.028 |
| Popis: | Cortical pores are determinants of the elastic properties and of the ultimate strength of bone tissue. An increase of the overall cortical porosity (Ct.Po) as well as the local coalescence of large pores cause an impairment of the mechanical competence of bone. Therefore, Ct.Po represents a relevant target for identifying patients with high fracture risk. However, given their small size, the in vivo imaging of cortical pores remains challenging. The advent of modern high-resolution peripheral quantitative computed tomography (HR-pQCT) triggered new methods for the clinical assessment of Ct.Po at the peripheral skeleton, either by pore segmentation or by exploiting local bone mineral density (BMD). In this work, we compared BMD-based Ct.Po estimates with high-resolution reference values measured by scanning acoustic microscopy. A calibration rule to estimate local Ct.Po from BMD as assessed by HR-pQCT was derived experimentally. Within areas of interest smaller than 0.5 mm2, our model was able to estimate the local Ct.Po with an error of 3.4%. The incorporation of the BMD inhomogeneity and of one parameter from the BMD distribution of the entire scan volume led to a relative reduction of the estimate error of 30%, if compared to an estimate based on the average BMD. When applied to the assessment of Ct.Po within entire cortical bone cross-sections, the proposed BMD-based method had better accuracy than measurements performed with a conventional threshold-based approach. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect