Differential Serodiagnostics of Latent Stages of Syphilis Based on Measuring IgG and IgM Levels towards Extended Panel of Recombinant Antigens of T. pallidum
| Autor: | Alexey A. Kubanov, M. V. Shpilevaya, G L Katunin, A. V. Runina |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine Protein Array Analysis Sensitivity and Specificity General Biochemistry Genetics and Molecular Biology law.invention 03 medical and health sciences 0302 clinical medicine Antigen law Late latent syphilis medicine Humans Potency Syphilis Treponema pallidum Immunoassay Antigens Bacterial business.industry T pallidum Discriminant Analysis General Medicine Middle Aged medicine.disease Serum samples Antibodies Bacterial 030104 developmental biology Immunoglobulin M Case-Control Studies Immunoglobulin G Healthy individuals Immunology Disease Progression Recombinant DNA Female business 030217 neurology & neurosurgery |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 169:470-473 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | Immunochips containing 12 recombinant antigens of T. pallidum (Тр15, Тр17, Тр47, TmpA, Тр0163, Тр0277, Тр0319, Тр0453, Тр0684, Тр0965, Тр0971, and Тр1038) were prepared to assay for IgG and IgM in serum samples (n=68) of healthy individuals and patients with the latent stages of syphilis. The linear discriminant analysis of detected IgG and IgM differentiated three groups of serum samples as 1) early latent syphilis; 2) seroresistant early latent syphilis; and 3) late latent syphilis with overall differentiation potency of 95.6% (88.9-100%). The samples of all syphilis patients were differentiated from the samples of healthy individuals with 100% specificity. |
| Databáze: | OpenAIRE |
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