Sexual Dimorphism of Cardiovascular Responses to Early Blockade of Bradykinin Receptors
| Autor: | Cindy Wang, Caroline Chao, Paolo Pinna Parpaglia, Vittorio Domenico Anania, Paolo Madeddu, Julie Chao, N. Glorioso |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
medicine.medical_specialty Bradykinin Blood Pressure Cardiovascular Physiological Phenomena chemistry.chemical_compound Subcutaneous injection Internal medicine Internal Medicine Animals Medicine Weaning Bradykinin receptor Bradykinin Receptor Antagonists Sex Characteristics Kidney business.industry Receptors Bradykinin Body Weight Antagonist Rats Sexual dimorphism Blood pressure Endocrinology medicine.anatomical_structure chemistry Female Kallikreins business |
| Zdroj: | Hypertension. 27:746-751 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.27.3.746 |
| Popis: | Abstract To assess whether the cardiovascular effects induced by early blockade of bradykinin B 2 -receptors with Hoe 140 ( d -Arg[Hyp 3 ,Thi 5 , d -Tic 7 ,Oic 8 ]-bradykinin) are influenced by sex, Wistar rats of both sexes received the antagonist (300 nmol/d per kilogram body wt) or vehicle from 2 days to 7 weeks of age by subcutaneous injection and then by intraperitoneal infusion. Compared with control rats, Hoe 140–treated female rats showed higher systolic blood pressure levels at 7 and 9 weeks of age (125±2 versus 111±2 mm Hg and 132±3 versus 116±2 mm Hg, respectively, P P P P P P |
| Databáze: | OpenAIRE |
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