The Irish Kidney Gene Project--Prevalence of Family History in Patients with Kidney Disease in Ireland
| Autor: | Dervla M. Connaughton, Sarah Bukhari, Peter Conlon, Eoin Cassidy, Michael O'Toole, Mardina Mohamad, John Flanagan, Triona Butler, Anne O'Leary, Limy Wong, John O'Regan, Sarah Moran, Patrick O'Kelly, Valerie Logan, Brenda Griffin, Matthew Griffin, Peter Lavin, Mark A. Little |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Population Autosomal dominant polycystic kidney disease Medical Records Young Adult Sex Factors Renal Dialysis Internal medicine medicine Polycystic kidney disease Prevalence Humans Family Genetic Predisposition to Disease Family history Age of Onset education Aged Aged 80 and over education.field_of_study Polycystic Kidney Diseases urogenital system business.industry Age Factors Glomerulonephritis Middle Aged medicine.disease Health Surveys Cross-Sectional Studies Etiology Female Kidney Diseases Age of onset business Ireland Kidney disease |
| Zdroj: | Nephron. 130(4) |
| ISSN: | 2235-3186 |
| Popis: | Background: The prevalence of kidney disease (KD) due to inherited genetic conditions in Ireland is unknown. The aim of this study was to characterise an adult kidney disease population in Ireland and to identify familial clusters of kidney disease within the population. Methods: This was a multicenter cross-sectional study of patients with kidney disease in the Republic of Ireland, from January 2014 to September 2014, recruiting from dialysis units and out-patient renal departments. A survey was performed by collecting data on etiology of kidney disease and whether a family history of kidney disease exists. Medical records were cross-referenced to confirm the etiology of kidney disease. Results: A total of 1,840 patients were recruited with a mean age of 55.9 years (range 17-94.5) and a male predominance (n = 1,095; 59.5%). A positive family history was reported by 629 participants (34.2%). Excluding polycystic kidney disease (n = 134, 7.3%), a positive family history was reported by 495 participants (26.9%). Kidney disease due to an unknown etiology was the commonest etiology in the non-polycystic kidney disease group with a positive family history (10.6%, n = 67). Kidney diseases that are not classically associated with familial inheritance including tubulo-interstitial kidney disease, congenital abnormalities of the kidney and urinary tract and glomerulonephritis demonstrated familial clustering. Conclusion: In an Irish non-polycystic kidney disease population, 26.9% reports a positive family history. The commonest etiology of kidney disease in the positive family history cohort, excluding autosomal dominant polycystic kidney disease, was kidney disease due to unknown etiology. Examining families with kidney disease provides an opportunity to better understand disease pathogenesis and potentially identify genetic predispositions to kidney disease. |
| Databáze: | OpenAIRE |
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