Antileukemic and Cytogenetic Activity by Triple Administration of Three Modified Steroidal Derivatives of Nitrogen Mustards
| Autor: | D.O. Onyango, S.S. Nikolaropoulos, Anna I. Koutsourea, Athanasios A. Papageorgiou, Evaggelia S. Arsenou, Dionysios Mourelatos, Manolis A. Fousteris, E. Karaberis |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Antineoplastic Agents Pharmacology Lethal Dose 50 Mice Drug Discovery Animals Humans Potency Pharmacology (medical) Lymphocytes Cells Cultured Cell Proliferation Antitumor activity Mice Inbred BALB C Leukemia P388 Chemistry Drug Synergism Combination chemotherapy General Medicine Xenograft Model Antitumor Assays Infectious Diseases Oncology Mice Inbred DBA Reduced toxicity Azasteroids Nitrogen Mustard Compounds Female P388 leukemia Sister Chromatid Exchange Androstanes |
| Zdroj: | Chemotherapy. 53:118-126 |
| ISSN: | 1421-9794 0009-3157 |
| DOI: | 10.1159/000099983 |
| Popis: | Combination chemotherapy is widely and routinely used for most cancer patients. The main objective of this study is an effort to develop new anticancer drugs and procedures with enhanced antitumor activity and reduced toxicity. This study was designed to determine the antileukemic and cytogenetic activity of five mixtures of three specific steroidal esters of aromatic nitrogen mustards in different proportions. This is the next step of two previous studies where the combination of two such esteric analogues was investigated with promising results. All of the five mixtures used proved active against leukemia P388 and in the induction of sister chromatid exchanges, indicating that the combination of the same class of compounds can be successful, especially when a highly potent agent is combined with another less active but probably mechanistically supplementary one. These results can be used in future experiments in order to further scout the specific role of the steroidal part of these molecules in the antileukemic potency of them. |
| Databáze: | OpenAIRE |
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