Cryptococcal choroiditis in advanced AIDS with clinicopathologic correlation
| Autor: | Jay M. Stewart, Christopher M. Aderman, Anthony Obeid, Ian R. Gorovoy, Daniel L. Chao, Michele M. Bloomer |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Cryptococcal choroiditis Enucleation Cryptococcus Autopsy 03 medical and health sciences 0302 clinical medicine lcsh:Ophthalmology Clinicopathologic correlation Medicine Meningitis 030212 general & internal medicine External limiting membrane Eye Disease and Disorders of Vision Brief report biology business.industry Neurosciences HIV Immunosuppression biology.organism_classification medicine.disease eye diseases AIDS Ophthalmology Choroiditis medicine.anatomical_structure lcsh:RE1-994 Cryptococcus neoformans 030221 ophthalmology & optometry Histopathology Radiology sense organs business |
| Zdroj: | American Journal of Ophthalmology Case Reports, Vol 10, Iss, Pp 51-54 (2018) American Journal of Ophthalmology Case Reports |
| ISSN: | 2451-9936 |
| Popis: | Purpose: To describe a case of disseminated cryptococcal meningitis with multifocal choroiditis and provide optical coherence tomography (OCT) findings correlated with described histopathology in a patient with advanced acquired immunodeficiency syndrome (AIDS). Observations: The patient was a 54-year-old man with AIDS who presented with dyspnea and headache followed by acute vision loss. OCT demonstrated a lesion with a small area of fluid that was limited by a more prominent and irregular external limiting membrane with underlying nodular choroidal thickening, mild RPE disorganization, and hyperreflectivity of the overlying photoreceptor layer. Patient was found to have disseminated cryptococcal infection and passed away despite aggressive therapy. Autopsy was performed including bilateral enucleation and a Cryptococcus lesion was confirmed on histopathology. Conclusion and importance: This case highlights the clinical, imaging, and histopathologic findings of cryptococcal choroiditis and provides a review of the updated treatment recommendations for disseminated infection in a patient with advanced AIDS. Although currently fundoscopy has proven most useful in directing the diagnostic algorithm in choroiditis in the setting of advanced immunosuppression, OCT may provide insight into the spread of Cryptococcus within the eye. Keywords: Cryptococcus neoformans, Cryptococcal choroiditis, Meningitis, HIV, AIDS, Clinicopathologic correlation |
| Databáze: | OpenAIRE |
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