A Case of Essential Thrombocythemia and IgA Nephropathy with Literature Review of the Concurrence
| Autor: | Timothy Johnson, Shoja Rahimian, Ronald Herb |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Pathology
medicine.medical_specialty medicine.diagnostic_test Thrombocytosis Essential thrombocythemia business.industry Fibrillary Glomerulonephritis 030232 urology & nephrology Renal function Case Report 030204 cardiovascular system & hematology lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease urologic and male genital diseases lcsh:RC254-282 Nephropathy 03 medical and health sciences 0302 clinical medicine Focal segmental glomerulosclerosis Oncology medicine Mesangial proliferative glomerulonephritis Renal biopsy business |
| Zdroj: | Case Reports in Oncological Medicine Case Reports in Oncological Medicine, Vol 2019 (2019) |
| ISSN: | 2090-6714 2090-6706 |
| Popis: | Myeloproliferative neoplasms such as essential thrombocythemia (ET) have been associated with glomerular disease on rare instances. A case of ET associated with immunoglobulin A nephropathy (IgAN) is described in a 57-year-old man with a history of hypertension. Progressively worsening renal function was noted in the patient along with unexplained mild thrombocytosis. Pathological review of renal biopsy identified IgAN concurrently with newly diagnosed JAK2-mutated ET. The patient was started on aspirin therapy and closely monitored for his renal function. A literature review of the association of ET and renal disease revealed nine cases of ET associated with IgAN, focal segmental glomerulosclerosis, and fibrillary glomerulonephritis. Comparison of the pathological features of the renal biopsies within the cases noted mesangial proliferation as a common finding, which has been described to be potentiated by platelet-derived growth factor (PDGF). This commonality may represent a link between ET and glomerular disease which deserves further attention in future cases. Improved management of such cases depends on the recognition of the combined occurrence of ET and glomerular diseases and uncovering the shared pathogenesis between platelets and glomeruli. |
| Databáze: | OpenAIRE |
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