The Implications of Pruritogens in the Pathogenesis of Atopic Dermatitis
| Autor: | Yu-Ta Yen, Lai-San Wong, Chih-Hung Lee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Neuroimmunomodulation QH301-705.5 Disease Review Models Biological Catalysis Dermatitis Atopic Inorganic Chemistry Pathogenesis 03 medical and health sciences 0302 clinical medicine Immune system Genetic predisposition Humans Medicine itch Renal Insufficiency Chronic Physical and Theoretical Chemistry Biology (General) skin and connective tissue diseases Molecular Biology QD1-999 Spectroscopy Cholestasis atopic dermatitis business.industry Transmission (medicine) Pruritus Organic Chemistry General Medicine Atopic dermatitis medicine.disease pruritogens Pathophysiology Computer Science Applications Chemistry 030104 developmental biology 030220 oncology & carcinogenesis Immunology Cytokines Itching Inflammation Mediators medicine.symptom business Histamine |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 7227, p 7227 (2021) |
| ISSN: | 1422-0067 |
| Popis: | Atopic dermatitis (AD) is a prototypic inflammatory disease that presents with intense itching. The pathophysiology of AD is multifactorial, involving environmental factors, genetic susceptibility, skin barrier function, and immune responses. A recent understanding of pruritus transmission provides more information about the role of pruritogens in the pathogenesis of AD. There is evidence that pruritogens are not only responsible for eliciting pruritus, but also interact with immune cells and act as inflammatory mediators, which exacerbate the severity of AD. In this review, we discuss the interaction between pruritogens and inflammatory molecules and summarize the targeted therapies for AD. |
| Databáze: | OpenAIRE |
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