The similarity of selected statins – a comparative analysis
| Autor: | Constantin Dreyer, Jacek Zagajewski, Wojciech Placha, Monika Piwowar, Jacek Dygut, Klaudia Stangel-Wójcikiewicz |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
General Computer Science business.industry Medicine (miscellaneous) Health Informatics Computational biology 030204 cardiovascular system & hematology Biochemistry Genetics and Molecular Biology (miscellaneous) 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Similarity (network science) Medicine business |
| Zdroj: | Bio-Algorithms and Med-Systems. 14 |
| ISSN: | 1896-530X 1895-9091 |
| DOI: | 10.1515/bams-2018-0034 |
| Popis: | The paper presents the physicochemical and structural characteristics as well as the comparison of selected statins. Statins are relatively popular compounds used in modern medicine. They are increasingly often combined with other medications to improve the effectiveness of therapy. We analyzed the characteristics of pravastatin, simvastatin, atorvastatin, pitavastatin, lovastatin, mevastatin, fluvastatin, and rosuvastatin obtained from the PubChem Substance database. On the basis of data related to chemical structure and physicochemical properties, the statins were grouped into more and less similar ones. Statins are not homogeneous in terms of physicochemical properties and structure. Three groups of statins were identified. Mevastatin, lovastatin, and simvastatin are the most similar to each other, while pravastatin shows a slightly lower similarity to them. Pitavastatin and fluvastatin are also highly similar, while atorvastatin and rosuvastatin, because of their properties, are the most different from other statin groups. |
| Databáze: | OpenAIRE |
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