A nested case-control study to evaluate the association between fetal growth restriction and vitamin B12 deficiency
| Autor: | Jiji Elizabeth Mathews, Ajit Sebastian, Kuruvilla P. Chacko, Anuja Abraham, Dibu Sam |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Pregnancy Trimester Third Nutritional Status Fetal Development Pregnancy Statistical significance medicine Humans Vitamin B12 Socioeconomic status Fetal Growth Retardation business.industry Surrogate endpoint Obstetrics Obstetrics and Gynecology Vitamin B 12 Deficiency General Medicine Infant Low Birth Weight Pregnancy Complications Low birth weight Social Class Case-Control Studies Cohort Nested case-control study Gestation Female medicine.symptom business |
| Zdroj: | The AustralianNew Zealand journal of obstetricsgynaecology. 53(4) |
| ISSN: | 1479-828X |
| Popis: | Objectives To study the association between maternal vitamin B12 levels and fetal growth restriction. Methods In this nested case–control study, a cohort of low-risk women attending the antenatal clinic had their blood samples taken and stored at 28–31 weeks gestation. They were followed until delivery. Fifty-eight women delivering babies less than 2500 g were taken as cases and an equal number of controls delivering babies more than 2500 g were taken from the same cohort. Their B12 levels were assayed and studied for statistical significance. Results The baseline characteristics of both groups were similar. The number of women with serum B12 levels less than 200 pg/mL were similar in both groups: 33% versus 29% (P = 0.84). Type of kitchen fuel used was taken as a surrogate marker for socioeconomic status. More women in the cases used non-LPG (liquid petroleum gas) kitchen fuels such as kerosene and wood than in controls, 35% versus 19% (P = 0.06). Conclusions No association between maternal vitamin B12 levels and fetal growth restriction was found in this study. Low birth weight babies were more common in women of low socioeconomic status. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text