Vulvar Cutaneous Myxoma in a Patient With Carney Complex: Avoiding Pitfalls of Myxoid Lesions of the Vulva
| Autor: | Jahg Wong, Simon F. Roy, Lifeng Gu, Vanessa Samouelian, France Berthelet, Kurosh Rahimi |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Adult
0301 basic medicine Pathology medicine.medical_specialty Deep Angiomyxoma Skin Neoplasms Context (language use) Subcutaneous fat Perivascular Lymphocytic Infiltrate Pathology and Forensic Medicine Vulva 03 medical and health sciences 0302 clinical medicine VULVAR LESION Biomarkers Tumor Humans Medicine Carney Complex Carney complex Vulvar Neoplasms business.industry medicine.disease Cutaneous myxoma 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female Surgery Anatomy business |
| Zdroj: | International Journal of Surgical Pathology. 30:33-38 |
| ISSN: | 1940-2465 1066-8969 |
| DOI: | 10.1177/10668969211020504 |
| Popis: | We present the case of a 31-year-old woman who underwent surgical excision for a polypoid, vulvar lesion. Histopathological analysis showed a diffuse myxoid stroma admixed with scant collagen fibrils. Thin-walled and branching blood vessels were prominent, with a mild perivascular lymphocytic infiltrate. Cytologically bland spindle cells with inconspicuous nucleoli were immersed in a loose myxoid stroma. This combination of histopathological features along with multinodularity in the subcutaneous fat raised concern for deep angiomyxoma, a locally destructive neoplasm. Among our differential of myxoid lesions of the vulva, we ultimately favored the diagnosis of vulvar cutaneous myxoma. Upon further investigation, we learned that our patient was indeed known for the Carney complex. We highlight that vulvar cutaneous myxomas arising in the context of the Carney complex pose a significant diagnostic challenge for pathologists and should not be overdiagnosed as aggressive lesions such as deep angiomyxoma or other malignant stromal neoplasms. |
| Databáze: | OpenAIRE |
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