Some antagonists of dantrolene sodium on the isolated diaphragm muscle of the rat
| Autor: | W. C. Bowman, H H Khan, A O Savage |
|---|---|
| Rok vydání: | 1977 |
| Předmět: |
Male
Epinephrine Pyridines Diaphragm Ionophore Pharmaceutical Science chemistry.chemical_element In Vitro Techniques Calcium Pharmacology Dantrolene Dantrolene Sodium chemistry.chemical_compound Caffeine medicine Animals Calcimycin Quinine Thiocyanate Hydantoins Electric Stimulation Rats chemistry Anesthesia Uranium Female Contracture medicine.symptom Thiocyanates Muscle Contraction medicine.drug |
| Zdroj: | Journal of Pharmacy and Pharmacology. 29:616-625 |
| ISSN: | 2042-7158 0022-3573 |
| DOI: | 10.1111/j.2042-7158.1977.tb11417.x |
| Popis: | The effects of a number of potential antagonists of dantrolene sodium have been studied on twitches of the isolated hemidiaphragm preparation of the rat stimulated directly at a frequency of 0·1 Hz, after complete neuromuscular block produced by tubocurarine or erabutoxin a. The substances selected as possible dantrolene antagonists were uranyl ions, thiocyanate ions, adrenaline, caffeine, quazodine, quinine, 4-aminopyridine and the calcium ionophore A23187, all of which facilitate excitation-contraction coupling in one way or another. Contracture was the main feature of the response to A23187, the increase in the tension of the dantrolene-depressed twitches being very slight. All the remaining compounds increased the amplitude of the twitches, but only 4-aminopyridine, quinine, quazodine and caffeine were capable of restoring to the control amplitude twitches that had been maximally depressed by dantrolene. Of these, 4-aminopyridine and quinine were the most potent on a molar basis. |
| Databáze: | OpenAIRE |
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