Effects of a single haloperidol application to neonatal and early postnatal rats on the neurotransmitter content in the corpus striatum

Autor: Renate Thiel, Rudolf Schwabe, Ibrahim Chahoud, Diether Neubert
Rok vydání: 1992
Předmět:
Zdroj: Archives of Toxicology. 66:573-579
ISSN: 1432-0738
0340-5761
DOI: 10.1007/bf01973388
Popis: We investigated the influence of the dopamine antagonist haloperidol on the neurotransmitter content in the developing rat brain. Dopamine (DA), serotonin (5-HT) and the corresponding metabolites dopac, HVA and HIAA were determined in the corpus striatum of the rat between day 1 and day 21 pn by HPLC with electrochemical detection. A consistent increase in the content of dopamine was found during postnatal development. The concentrations (ng/g wet tissue; mean ±standard deviation) increased from 793±237 on day 1 pn to 4584±581 on day 21 pn, but remained still lower than in adult animals (9763±494). Similar results were found for the metabolites dopac and HVA. The content of dopac increased from 59±22 (day 1 pn) to 551±59 (day 21 pn) and the content of HVA from 53±18 (day 1 pn) to 419±41 (day 21 pn). Both metabolites were also about two times lower than in adult animals (dopac 1090± 282, HVA 744± 206). In contrast to dopamine and its metabolites we found no age-dependent changes in the content of 5-HT from day 1 pn (99± 11) to day 14 pn(121±21). A remarkable increase in the content of 5-HT was seen from day 14 pn to day 21 pn (438±56), reaching almost adult levels (570±92). The metabolite HIAA was nearly three times higher on day 21 pn (610±123) than on day 14 pn (223±28) and two times higher than in adults (321±58). One hour after application of haloperidol to the pups (1 mg/kg body wt i.p.) a significant increase (i.e. day 21 pn) of dopac (1755±496) and HVA (966±279), but not of 5-HT (382±72) or HIAA (614±130) was detected.
Databáze: OpenAIRE
Externí odkaz: