Deficiency of fat-soluble vitamins in chronic pancreatitis: A systematic review and meta-analysis
| Autor: | Serena Stigliano, Aleksandra Kaczka, Peter Simon, Emma Martínez-Moneo, Aleksandra Hedström, Gabriele Capurso, Marko Malvik, Alexander Waldthaler, Patrick Maisonneuve |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Vitamin
medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment pancreatitis Prevalence vitamin D aitamin A deficiency vitamin E Gastroenterology vitamin A vitamin D deficiency chronic pancreatitis vitamin K 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Pancreatitis Chronic Vitamin K deficiency medicine Vitamin D and neurology Humans Vitamin E Deficiency Hepatology business.industry Vitamin A Deficiency Vitamin E Avitaminosis medicine.disease Vitamin D Deficiency meta-analysis chronic Endocrinology Fat-Soluble Vitamin chemistry 030220 oncology & carcinogenesis Meta-analysis 030211 gastroenterology & hepatology Vitamin K Deficiency fat-soluble vitamins business avitaminosis humans pancreatitis chronic prevalence vitamin E deficiency vitamin K deficiency |
| Zdroj: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]. 16(6) |
| ISSN: | 1424-3911 |
| Popis: | Background and aims Chronic pancreatitis (CP) patients are at risk for fat-soluble vitamins (A, D, E, K) deficiency, but available studies are small and heterogeneous. We conducted a systematic review and meta-analysis to determine the prevalence of fat–soluble vitamins deficiency in CP patients. Methods Medline was searched up to January 2016 for case series and case-control studies reporting prevalence of fat-soluble vitamin deficiency in CP patients. The prevalent deficiency rate was pooled for included studies, and deficiency rate between CP and controls, with relative odds ratio (OR) and 95% confidence interval (CI) calculated for case-control studies. Results Twelve studies including 548 patients included. With a random-effect model, the pooled prevalence rate of vitamin A, D and E deficiency were 16.8% (95%CI 6.9–35.7), 57.6% (95%CI 43.9–70.4) and 29.2% (95%CI 8.6–64.5) respectively, with considerable heterogeneity (I 2 = 75%, 87.1% and 92%). Only one study evaluated vitamin K deficiency. The pooled OR for vitamin D deficiency in CP cases compared with controls was 1.17 (95% CI 0.77–1.78). Sensitivity analyses showed lower prevalence of vitamin A and E, and higher prevalence of vitamin D deficiency in high-quality studies. The rate of pancreatic exocrine insufficiency did not seem affect the deficiency rates, while the use of different cut-offs influences results and heterogeneity for vitamin E, but not A. Conclusions Fat-soluble vitamins deficiency is frequent in CP patients, with considerable heterogeneity. There is, however, no apparent increased risk of vitamin D deficiency in CP compared to controls. Larger, high-quality studies are necessary to better estimate the prevalence of fat-soluble vitamins deficiency, including vitamin K. |
| Databáze: | OpenAIRE |
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