Prolonged Auditory Brainstem Response in Universal Hearing Screening of Newborns with Autism Spectrum Disorder

Autor: Guangyu Zeng, Jillian N. Gerstenberger, Elizabeth A. Simpson, Kun-Hsing Yu, Isaac S. Kohane, Christine E F Delgado, Anibal Gutierrez, Oren Miron, Rafael E. Delgado
Rok vydání: 2020
Předmět:
Adult
medicine.medical_specialty
Future studies
genetic structures
Autism Spectrum Disorder
NEUROIMAGING
Short Report
Stimulus (physiology)
Audiology
behavioral disciplines and activities
Hearing screening
03 medical and health sciences
0302 clinical medicine
Hearing
children
Event-related potential
mental disorders
event‐related potential
medicine
otorhinolaryngologic diseases
Evoked Potentials
Auditory
Brain Stem
Humans
0501 psychology and cognitive sciences
auditory
Autistic Disorder
Child
Genetics (clinical)
Aged
Retrospective Studies
medicine.diagnostic_test
business.industry
infants
General Neuroscience
05 social sciences
Infant
Newborn
medicine.disease
Auditory brainstem response
Autism spectrum disorder
Autism
Hearing test
biomarker
Neurology (clinical)
business
030217 neurology & neurosurgery
050104 developmental & child psychology
Zdroj: Autism Research
ISSN: 1939-3806
Popis: Previous studies report prolonged auditory brainstem response (ABR) in children and adults with autism spectrum disorder (ASD). Despite its promise as a biomarker, it is unclear whether healthy newborns who later develop ASD also show ABR abnormalities. In the current study, we extracted ABR data on 139,154 newborns from their Universal Newborn Hearing Screening, including 321 newborns who were later diagnosed with ASD. We found that the ASD newborns had significant prolongations of their ABR phase and V-negative latency compared with the non-ASD newborns. Newborns in the ASD group also exhibited greater variance in their latencies compared to previous studies in older ASD samples, likely due in part to the low intensity of the ABR stimulus. These findings suggest that newborns display neurophysiological variation associated with ASD at birth. Future studies with higher-intensity stimulus ABRs may allow more accurate predictions of ASD risk, which could augment the universal ABR test that currently screens millions of newborns worldwide. LAY SUMMARY: Children with autism spectrum disorder (ASD) have slow brain responses to sounds. We examined these brain responses from newborns' hearing tests and found that newborns who were later diagnosed with autism also had slower brain responses to sounds. Future studies might use these findings to better predict autism risk, with a hearing test that is already used on millions of newborns worldwide.
Databáze: OpenAIRE
Externí odkaz: