Use of direct oral anticoagulants in cerebral venous thrombosis: a systematic review
| Autor: | Aliza T. Brown, Sanjeeva Onteddu, Hisham Elkhider, Krishina Nalleballe, Naga Venkata Pothineni, Kelly-Ann Patrice, Sen Sheng, Saritha Ranabothu, Rohan Sharma, Nidhi Kapoor |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Side effect Treatment outcome MEDLINE Administration Oral Hemorrhage 030204 cardiovascular system & hematology law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Modified Rankin Scale law Internal medicine medicine Humans Good outcome Stroke Venous Thrombosis business.industry Hematology General Medicine medicine.disease Venous thrombosis Treatment Outcome Intracranial Thrombosis business Factor Xa Inhibitors 030215 immunology |
| Zdroj: | Blood Coagulation & Fibrinolysis. 31:501-505 |
| ISSN: | 1473-5733 0957-5235 |
| DOI: | 10.1097/mbc.0000000000000958 |
| Popis: | We are here to review the efficacy and safety of direct oral anticoagulants (DOACs) in the treatment of Cerebral Venous Thrombosis (CVT). A search strategy was developed with a research librarian. All published articles including trials, studies, case series, and case reports were reviewed from NCBI/PubMed up to May 2019 by two independent reviewers. A total of 11 studies were identified, which included 70 patients with CVT on DOACs. After 6 months follow-up more than 86.7% of these patients had a good outcome on the Modified Rankin Scale (mRS) of 0--1 at 6 months and no recurrence of venous thromboembolic events (VTE) at 12 months. Recanalization rate at 6 months varied from 55 to 100%. Only two patients had a side effect of minor bleeding because of DOAC usage. Although the current American Heart Association/American Stroke Association and European Stroke Organization guidelines do not endorse the use of DOACs for treatment of CVT because of lack of evidence from large randomized clinical trials, Use of DOACs in CVT appears to be well tolerated and efficacious with favorable outcomes. Further evidence is needed to establish their use in CVT. |
| Databáze: | OpenAIRE |
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