Classification of 3097 patients from the Japanese melanoma study database using the American joint committee on cancer eighth edition cancer staging system
| Autor: | Akane Minagawa, Manabu Yoshioka, Akiko Kishi, Naoki Murata, Hiroshi Uchi, Kanako Matsuyama, Tatsuya Kaji, Susumu Fujiwara, Yoshiyuki Nakamura, Kazuyasu Fujii, Manabu Fujimoto, Tatsuya Takenouchi, Shusuke Yoshikawa, Satoshi Fukushima, Norito Katoh, Junji Kato, Naoki Noma, Dai Ogata, Yasuhiro Fujisawa, Yasuhiro Nakamura, Naohito Hatta, Takatoshi Shimiauchi, Masashi Ishikawa, Toshiharu Fujiyama, Daisuke Yamada, Taku Fujimura, Jun Asai, Hironobu Ihn, Toshihiko Hoashi, Kenji Yokota, Kenjiro Namikawa, Yoshitsugu Shibayama, Jiro Uehara |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Skin Neoplasms Databases Factual Population Antineoplastic Agents Kaplan-Meier Estimate Dermatology computer.software_genre Biochemistry Disease-Free Survival Cohort Studies 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Japan Epidemiology Humans Medicine Stage (cooking) education Melanoma Molecular Biology Survival analysis Neoplasm Staging Cancer staging education.field_of_study Database business.industry Cancer Prognosis medicine.disease 030104 developmental biology Chemotherapy Adjuvant Lymphatic Metastasis Cohort Neoplasm Recurrence Local business computer |
| Zdroj: | Journal of Dermatological Science. 94:284-289 |
| ISSN: | 0923-1811 |
| Popis: | Background The American Joint Committee on Cancer (AJCC) 8th Edition Cancer Staging System was implemented in 2018; however, it has not been validated in an Asian melanoma population. Objective The purpose of this study was to validate the new system using a cohort of Japanese melanoma patients. Methods The AJCC 7th and 8th Editions were used for TNM classification of patients in a database established by the Japanese Melanoma Study Group. Patient data with sufficient information to be applicable to the AJCC 8th staging were selected. The Kaplan–Meier method was used to estimate disease-specific survival and relapse-free survival. Results In total, data for 3097 patients were analyzed. The 5-year disease-specific survival according to the 7th and 8th Edition staging system were as follows: IA = 98.5%/97.9%; IB = 95.4%/96.2%; IIA = 94.2%/94.1%; IIB = 84.6%/84.4%; IIC = 72.2%/72.2%; IIIA = 76.2%/87.5%; IIIB = 60.7%/72.6%; IIIC = 42.0%/55.3% and IIID = none/26.0%. The 5-year relapse-free survival according to the 7th and 8th Edition staging was as follows: IA = 94.5%/92.7%; IB = 85.4%/85.3%; IIA = 80.1%/79.4%; IIB = 71.4%/70.6%; IIC = 56.8%/55.7%; IIIA = 56.8%/69.4%; IIIB = 42.6%/56.8%; IIIC = 20.0%/33.3% and IIID = none/6.5%. Conclusion The results show that new staging system could efficiently classify our Japanese melanoma cohort. Although there was no difference in Stage I and II disease between the 7th and 8th Edition systems, we should be careful in managing Stage III disease since the survival curves of the 8th Edition staging were completely different from the 7th Edition. Moreover, our results indicate that adjuvant therapies for Stage IIB and IIC should be developed, since the relapse-free survival for these stages were equivalent to Stage IIIA and IIIB, respectively. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect