Improving the relaxivity by dimerizing Gd-AAZTA: Insights for enhancing the sensitivity of MRI contrast agents

Autor:	Bo Song, Eliana Gianolio, Kondareddiar Ramalingam, Rolf E. Swenson, Ferenc K. Kálmán, Silvio Aime
Jazyk:	angličtina
Rok vydání:	2010
Předmět:	Inorganic Chemistry Gadolinium-Chelate chemistry.chemical_compound Nuclear magnetic resonance Coordination sphere Természettudományok Mri imaging Chemistry Materials Chemistry Molecule Physical and Theoretical Chemistry Kémiai tudományok Derivative (chemistry)
Popis:	The synthesis of a dimeric derivative of Gd-AAZTA is reported. It retains the basic properties of the parent complex ( q = 2, high stability) and displays a relaxivity of 14.0 mM − 1 s − 1 at 20 MHz and 298 K. The outstanding relaxivity is the result of the increased molecular reorientational time and of the contribution arising from 4 to 5 water molecules in the second coordination sphere of the Gd(III) ions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2efdeb5a53e460df396e5efde11cc9b http://hdl.handle.net/2318/74184 Zobrazit plný text záznamu